Genetic background predisposing the drug-induced long QT syndrome.
نویسندگان
چکیده
منابع مشابه
Drug-induced long QT syndrome.
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an electrophysiologic curiosity to a centerpiece in drug regulation and development. This evolution reflects an increasing recognition that a rare adverse drug effect can profoundly upset the balance between benefit and risk that goes into the prescription of a drug by an individual practitioner as well as the...
متن کامل[Long QT syndrome: genetic implications and drug influence].
QT interval u elektrokardiogramu (EKG) je interval od početka Q zupca do završetka T talasa i ekvivalent je akcionog potencijala komora, tj. njihove depolarizacije i repolarizacije. Na njegovu dužinu utiču frekvencija srčanog rada, godine života i pol. Kao preciznija mera srčanog ciklusa komora uzima se korigovana vrednost QT intervala (QTc) koja se izračunava po Bazettovoj formuli tako što se ...
متن کاملImpact of Drug Induced Long QT Syndrome: A Systematic Review
Background Drug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown. Methods PubMed and EMBASE databases (until May 2, 2017) were searched to identify studies reporting drug induced long QT syndrome and followed the PRISMA guidelines. The main outcomes measured in these studies were QTc prolongation, ventricular arrhythmias, torsade de pointes (TdP) a...
متن کاملDrug-induced long QT syndrome and Torsade de Pointes.
Several medications, including drugs prescribed for noncardiac indications, have been associated with a prolongation of the QT interval on the surface electrocardiogram. Under certain circumstances, this clinical manifestation may reflect an increased risk for patients presenting with a polymorphic ventricular tachycardia known as torsade de pointes. Drugs that prolong the QT interval belong to...
متن کاملCauses and management of drug-induced long QT syndrome.
Long QT syndrome (LQTS) is characterized by inherited or acquired prolonged QT interval on the surface electrocardiogram. This can lead to torsade de pointes ventricular tachycardia (TdP VT) and ventricular fibrillation. In the acquired form of the disease, medications from several classes can cause TdP VT or potentiate the electrocardiographic findings. These include class IA and III antiarrhy...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.121.401